| 宋震宇,胡华,刘勇,甘中华.前列腺癌ADC值与Gleason评分及Ki-67、P53蛋白表达的相关性[J].中国医学影像技术,2019,35(2):236~239 |
| 前列腺癌ADC值与Gleason评分及Ki-67、P53蛋白表达的相关性 |
| Correlation of ADC value and Gleason score, Ki-67, P53 proteins expression in prostate cancer |
| 投稿时间：2018-06-12 修订日期：2018-10-16 |
| DOI：10.13929/j.1003-3289.201806056 |
| 中文关键词: 前列腺肿瘤 表观扩散系数 Gleason评分 蛋白表达 |
| 英文关键词:prostate neoplasms apparent diffusion coefficient Gleason score proteins expression |
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| 中文摘要: |
| 目的 探讨DWI ADC值与前列腺癌Gleason评分及Ki-67、P53蛋白表达的相关性。方法 收集59例接受DWI检查并经病理证实的前列腺癌患者，病理组织均经Ki-67和P53免疫组织化学染色。根据镜下癌细胞及间质的分化程度进行Gleason评分，将其分别纳入高分化组（<7分，n=17）、中分化组（7~8分，n=23）或低分化组（>8分，n=19）。比较各组间ADC值的差异，分析病灶ADC值与Gleason评分及Ki-67、P53蛋白表达的相关性。结果 59例前列腺癌病灶的ADC值为（0.98±0.19）×10-3 mm2/s，高分化、中分化和低分化组ADC值分别为（1.14±0.17）×10-3 mm2/s、（1.05±0.17）×10-3 mm2/s和（0.88±0.24）×10-3 mm2/s，总体和两两比较差异均有统计学意义（P均<0.05）。前列腺癌ADC值与Gleason评分、Ki-67和P53蛋白表达均呈负相关（rs=-0.611、-0.491、-0.511，P=0.019、0.016、0.021）。结论 前列腺癌ADC值分别与Gleason评分及Ki-67、P53蛋白表达呈负相关。通过ADC值可初步评价前列腺癌的恶性程度及细胞分化、增殖程度。 |
| 英文摘要: |
| Objective To explore the correlation of DWI ADC value and Gleason score, Ki-67, P53 proteins expression in prostate cancer, respectively. Methods Totally 59 patients with prostate cancer who had pathological data were enrolled and underwent DWI examination. The pathological samples were stained with Ki-67, P53 using immunohistochemistry staining. Then Gleason score was used to evaluate the degree of differentiation of tumor cells and stroma, and the patients were divided into well-differentiated group (<7 scores, n=17), moderately-differentiated group (7-8 scores, n=23) and poorly-differentiated group (>8 scores, n=19). The differences of ADC value and the correlation with Ki-67 and P53 were analyzed. Results The ADC value of prostate cancer was (0.98±0.19)×10-3 mm2/s in all 59 patients, while in well-differentiated group, moderately-differentiated group and poorly-differentiated group was (1.14±0.17)×10-3 mm2/s, (1.05±0.17)×10-3 mm2/s and (0.88±0.24)×10-3 mm2/s, respectively, and the differences were significant in total and each pairwise comparison (all P<0.05). ADC value of prostate cancer was negatively correlated with Gleason score (rs=-0.611, P=0.019), the expression of Ki-67 (rs=-0.491, P=0.016) and P53 protein (rs=-0.511, P=0.021), respectively. Conclusion ADC value of prostate cancer is negatively correlated with Gleason score and Ki-67, P53 proteins expression. ADC value can be used to preliminarily and noninvasively predict the malignancy degree of tumor cells, the degree of cell differentiation and proliferation in prostate neoplasm. |
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