陈基明,李周丽,朱晴,张爱娟,颜秀芳,邢滔.DWI和动态增强MRI定量参数诊断子宫内膜癌肌层浸润[J].中国医学影像技术,2019,35(2):226~230
DWI和动态增强MRI定量参数诊断子宫内膜癌肌层浸润
Quantitative parameters of DWI and dynamic contrast-enhanced MRI in evaluating the depth of myometrial invasion ofendometrial carcinoma
投稿时间:2018-05-24  修订日期:2018-10-06
DOI:10.13929/j.1003-3289.201805139
中文关键词:  子宫内膜肿瘤  磁共振成像  对比剂
英文关键词:endometrial neoplasms  magnetic resonance imaging  contrast media
基金项目:
作者单位E-mail
陈基明 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001 yjsyycjm@126.com 
李周丽 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001  
朱晴 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001  
张爱娟 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001  
颜秀芳 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001  
邢滔 皖南医学院弋矶山医院医学影像中心, 安徽 芜湖 241001  
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中文摘要:
      目的 探讨DWI和动态对比增强MRI(DCE-MRI)定量参数诊断子宫内膜癌浸润深度的价值。方法 回顾性分析45例经手术病理证实为子宫内膜样腺癌患者的资料,均于术前1~2周接受常规MRI及DWI、DCE-MRI。根据病理结果按子宫内膜癌肌层浸润深度分为无或浅肌层浸润组(n=25)和深肌层浸润组(n=20),比较2组间ADC值及DCE-MRI定量参数值(Ktrans、Kep、Ve)的差异;绘制ROC曲线,评价有统计学差异的参数诊断子宫内膜癌肌层浸润深度的效能。结果 子宫内膜癌深肌层浸润组Ktrans值高于无或浅肌层浸润组,差异有统计学意义(P=0.016),2组间ADC值、Kep、Ve差异均无统计学意义(P均>0.05)。Ktrans诊断子宫内膜癌肌层浸润深度的ROC曲线下面积为0.735(P=0.007),以Ktrans=0.355/min为临界值,诊断子宫内膜癌肌层浸润深度的敏感度、特异度分别为80.0%、60.0%。结论 DCE-MRI定量参数中,Ktrans值有助于评估子宫内膜癌肌层侵犯深度。
英文摘要:
      Objective To explore the value of DWI and dynamic contrast enhanced-MRI (DCE-MRI) quantitative parameters in evaluating the depth of myometrial invasion in patients with endometrial cancer. Methods Data of 45 patients with endometrioid adenocarcinoma confirmed by surgery and pathology were retrospectively analyzed. All patients underwent routine MRI, DWI and DCE-MRI 1-2 weeks before surgery. The patients were divided into no or superficial myometrial invasion group (n=25) and deep myometrial invasion group (n=20) according to the pathological results. The differences of ADC value and DCE-MRI quantitative parameters (Ktrans, Kep, Ve) were compared between the two groups. ROC curve was used to evaluate the diagnostic efficacy for depth of myometrial invasion in endometrial carcinoma. Results Ktrans value of deep myometrial invasion group was higher than that of no or superficial myometrial invasion group (P=0.016). There was no significant difference in ADC value, Kep nor Ve between the two groups (all P>0.05). ROC curve analysis showed that the area under the curve of Ktrans was 0.735 (P=0.007). Taken Ktrans=0.355/min as the threshold, the sensitivity was 80.0%, and the specificity was 60.0% in diagnosis of depth of myometrial invasion in endometrial carcinoma. Conclusion Ktrans may be useful for evaluating the depth of myometrial invasion of endometrial carcinoma.
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