| 徐磊,周蕾蕾,孟庆乐,杨瑞,钱鑫宇,赵震宇,王峰.基于患者体质量指数的68Ga-DOTA-NOC PET/CT最佳采集条件[J].中国医学影像技术,2018,34(11):1707~1711 |
| 基于患者体质量指数的68Ga-DOTA-NOC PET/CT最佳采集条件 |
| Optimal acquisition protocols of 68Ga-DOTA-NOC PET/CT imaging based on patient's body mass index |
| 投稿时间：2018-03-08 修订日期：2018-06-22 |
| DOI：10.13929/j.1003-3289.201803046 |
| 中文关键词: 68Ga-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-1-柰丙氨酸-奥曲肽 人体质量指数 体层摄影术,X线计算机 体层摄影术,发射型计算机 图像质量 |
| 英文关键词:68Ga-DOTA-1-Nal3-octreotide Body mass index Tomography, X-ray computed Tomography, emission-computed Image quality |
| 基金项目:国家自然科学基金（81271604）、南京医科大学科技发展基金面上项目（2017NJMU127）。 |
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| 中文摘要: |
| 目的 探讨基于患者体质量指数（BMI）的68Ga-1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸-1-柰丙氨酸-奥曲肽（DOTA-NOC）PET/CT最佳采集条件。方法 收集89例接受68Ga-DOTA-NOC PET/CT全身扫描的神经内分泌肿瘤患者，根据体质量指数分为偏瘦组（n=13）、正常组（n=40）、超重组（n=31）和肥胖组（n=5）。以真符合计数率、随机符合计数率、等效噪声比（NECR）、随机分数和变异系数（CV）评估PET图像质量，分析其与BMI的关系，并比较4组间差异。结果 89例患者平均BMI为（22.99±3.77）kg/m2，68Ga-DOTA-NOC注射剂量为（1.04±0.27）MBq/kg体质量。真符合计数率、随机符合计数率和NECR均与显像剂注射剂量呈线性正相关（r=0.71、0.71、0.72，P均<0.01）。NECR在显像剂注射剂量约为1.65 MBq/kg体质量时获得最大值。4组真符合计数率差异有统计学意义（F=6.26，P<0.01），且BMI正常组患者真符合计数率与偏瘦组、超重组和肥胖组的比值分别为0.82、1.12和1.28。CV值随显像剂注射剂量的增加而下降（r=0.78，P<0.01），4组间差异有统计学意义（F=16.48，P<0.01）。4组间随机分数差异无统计学意义（F=1.33，P=0.27）。结论 基于患者BMI，68Ga-DOTA-NOC PET/CT推荐方案如下：偏瘦患者显像剂注射剂量参考范围为1.05~1.15 MBq/kg体质量，最大不超过1.30 MBq/kg体质量；超重患者和肥胖患者的每床位采集时间分别延长1.2~1.3倍和1.3~1.5倍。 |
| 英文摘要: |
| Objective To explore the optimal acquisition protocols for 68Ga-DOTA-1-Nal3-octreotide (68Ga-DOTA-NOC) PET/CT imaging based on patient's body mass index (BMI). Methods Totally 89 patients with neuroendocrine neoplasm (NEN) underwent whole body 68Ga-DOTA-NOC PET/CT scanning. The patients were classified into 4 groups based on BMI, including underweight group (n=13), normal weight group (n=40), overweight group (n=31) and obese group (n=5). PET image quality was measured with true coincidence rate, random coincidence rate, noise-equivalent counting rate (NECR), random fraction and coefficient of variance (CV) and compared among 4 groups, and their relationship with patient's BMI were analyzed. Results The mean BMI of 89 patients was (22.99±3.77)kg/m2, and the injection dose was (1.04±0.27)MBq/kg. The true coincidence rate, random coincidence rate and NECR had positive correlation with injection dose (r=0.71, 0.71, 0.72, all P<0.01). NECR got the maximum value at 1.65 MBq/kg. The true coincidence rate was significantly different among the 4 groups (F=6.26, P<0.01), and the ratio of that for underweight group, overweight group and obese group to normal weight group was approximately 0.82, 1.12 and 1.28, respectively. Meanwhile, CV significantly decreased with the increasing of injection dose (r=0.78, P<0.01). There was significant difference of CV among 4 groups (F=16.48, P<0.01). The average random fraction had no significant difference among 4 groups (F=1.33, P=0.27). Conclusion The recommended acquisition protocol for 68Ga-DOTA-NOC PET/CT imaging based on BMI is as follows:For underweight patients, the injection dose should be approximately 1.05-1.15 MBq/kg, and the maximum injected dose is less than 1.30 MBq/kg, while the optimal acquisition time per bed should be at least 1.2-1.3 times longer in overweight patients and 1.3-1.5 times longer in obese patients. |
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