| 陈淑娟,李晓舒,李小虎,王海宝,朱佳佳,田仰华,周珊珊,吴兴启,余永强.阿尔茨海默病患者脑功能网络小世界属性改变及其与认知功能的相关性[J].中国医学影像技术,2018,34(11):1632~1636 |
| 阿尔茨海默病患者脑功能网络小世界属性改变及其与认知功能的相关性 |
| Changes of small-world properties of functional brain networks and correlation with cognition in patients with Alzheimer disease |
| 投稿时间：2018-07-02 修订日期：2018-09-17 |
| DOI：10.13929/j.1003-3289.201807011 |
| 中文关键词: 阿尔茨海默病 静息态 功能磁共振成像 小世界网络 |
| 英文关键词:Alzheimer disease Resting-state Functional magnetic resonance imaging Small-world network |
| 基金项目:国家自然科学基金（81771817、81571308）、中国博士后科学基金（2017M612090）、安徽省高校科学研究重点项目（KJ2018A0197）。 |
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| 中文摘要: |
| 目的 利用图论分析方法观察阿尔茨海默病（AD）患者脑功能网络小世界属性改变及其与认知功能的相关性。方法 对42例AD患者（AD组）和31名正常志愿者（对照组）进行神经心理学评估，并采集静息态fMRI数据，构建小世界网络，计算小世界网络属性参数，包括聚类系数（Cp）、最短路径长度（Lp）、标准化聚类系数（γ）、标准化最短路径长度（λ）及小世界性（σ）。以独立样本t检验比较2组间小世界网络属性的差异，以偏相关分析评估小世界网络属性与认知评分的相关性。结果 在不同稀疏度下，AD组及对照组σ均>1，表示AD患者及正常受试者脑功能网络均具有小世界属性。AD组小世界属性参数Lp、λ大于对照组（P均<0.05），AD组与对照组间Cp、γ差异均无统计学意义（P均>0.05）。AD患者Cp与听觉词语学习测验（AVLT，即时）、AVLT（延迟）评分呈正相关（r=0.646，P<0.001；r=0.438，P=0.008），Lp与AVLT（即时）评分呈负相关（r=-0.381，P=0.035）。结论 AD患者脑功能网络的小世界属性发生改变，且与情景记忆能力具有相关性。脑功能网络小世界属性改变能够较好地反映AD患者的病理生理改变。 |
| 英文摘要: |
| Objective To investigate the changes of small-world properties of functional brain networks and their correlations with cognition in Alzheimer disease (AD) patients using graph theory analysis method. Methods Neuropsychological assessment and resting-state fMRI data were acquired in 42 AD patients (AD group) and 31 normal volunteers (control group). Firstly the small-world network was constructed, then the small-world properties, including the clustering coefficients (Cp), shortest path length (Lp), normalized clustering coefficients (γ), normalized shortest path length (λ) and small-worldness (σ) were calculated. The changes of relevant parameters between AD group and control group were examined using two-sample t tests, and partial correlation analysis was used to observe the correlation between small-world network properties and cognition. Results Under the range of different sparsities, σ>1 was found in both groups, indicating that the property of the functional networks in AD and control groups fit the definition of small-worldness. Lp and λ of the small-world network in AD group were significantly greater than those in control group (both P<0.05), while there was no significant difference of Cp and γ between the 2 groups (both P>0.05). Cp of AD group was positively correlated with the performance of auditory verbal learning test (AVLT, immediate) scores and AVLT (delay) scores (r=0.646, P<0.001; r=0.438, P=0.008). Lp in AD group was negatively correlated with AVLT (immediate, r=-0.381, P=0.035). Conclusion The small-world properties of functional brain networks in AD patients changes and significantly correlates with the performance of episodic memory. The changes of small-world network properties of functional brain network might reflect the pathophysiological changes of AD patients. |
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