| 黄振宇,李武铭,江桂华.氨基质子饱和转移效应MRI技术研究进展[J].中国医学影像技术,2018,34(9):1422~1425 |
| 氨基质子饱和转移效应MRI技术研究进展 |
| Research progresses of amide proton transfer MRI techniques |
| 投稿时间：2018-01-03 修订日期：2018-05-15 |
| DOI：10.13929/j.1003-3289.201801020 |
| 中文关键词: 磁共振成像 氨基质子饱和转移 成像序列 水脂分离 |
| 英文关键词:Magnetic resonance imaging Amide proton transfer Imaging sequence Water fat separation |
| 基金项目: |
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| 中文摘要: |
| 近年来，氨基质子饱和转移MRI（APT-MRI）技术在动物实验与临床研究中均取得突破性成果，促进了APT-MRI序列的改进和成像设备的更新。APT-MRI可探测内源性游离蛋白质和缩氨酸含量，临床用于诊断脑肿瘤、脑卒中等疾病。本文针对APT-MRI技术的关键点，对其成像基本原理、序列发展和序列改进特点、数据采集方法和临床运用以及未来发展和研究趋势进行综述。 |
| 英文摘要: |
| In recent years, amide proton transfer MRI (APT-MRI) technology has made a breakthrough in animal experiments and clinical applications, which promoted the improvement of APT-MRI sequences and the updating of imaging equipments. APT-MRI has an advantage in detecting endogenous free protein and peptides content, and is clinically applied to the diagnosis of diseases such as brain tumors and stroke. Focusing on the key point of APT-MRI technology, the basic principles of imaging, the development of imaging sequences and the characteristics of sequence improvement, data acquisition methods, clinical application and future development were reviewed in this article. |
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