| 余海歌,何文,程令刚,金占强,刘梦泽,魏世纪,李海欣.胶质瘤术中超声表现与免疫组化分子标记物表达的相关性[J].中国医学影像技术,2018,34(6):831~835 |
| 胶质瘤术中超声表现与免疫组化分子标记物表达的相关性 |
| Correlation of intraoperative ultrasonography and immunohistochemical markers expression in glioma |
| 投稿时间：2017-11-19 修订日期：2018-03-29 |
| DOI：10.13929/j.1003-3289.201711091 |
| 中文关键词: 胶质瘤 术中超声 Ki-67抗原 异柠檬酸脱氢酶1 免疫组织化学 |
| 英文关键词:Glioma Intraoperative ultrasound Ki-67 antigen Isocitrate dehydrogenase 1 Immunohistochemistry |
| 基金项目:国家自然科学基金（8173000716）、中国医师协会科技新星计划（2017003）、北京市属医院科研培育计划（PX2018021）。 |
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| 中文摘要: |
| 目的 探讨脑胶质瘤术中超声声像图特征与免疫组化分子标记物的相关性。方法 收集经手术病理证实的116例胶质瘤患者的资料，分析其声像图特征（肿瘤主要部位、最大径、边界、囊变、钙化、瘤周水肿程度及CDFI血流分级）与免疫组化分子标记物Ki-67、异柠檬酸脱氢酶1（IDH1）表达的相关性。结果 单因素分析显示，肿瘤边界、瘤周水肿及CDFI血流分级在Ki-67阴性与阳性患者间，肿瘤边界、囊变、瘤周水肿在IDH1阴性与阳性患者间差异均有统计学意义（P均<0.01）。多因素分析显示，边界清晰、瘤周水肿程度高、CDFI血流丰富的胶质瘤Ki-67阳性率高，边界模糊、瘤周水肿程度低的胶质瘤IDH1阳性率高。结论 超声声像图显示 |
| 英文摘要: |
| Objective To investigate the correlation between intraoperative ultrasonographic features and expression of immunohistochemical markers in patients with glioma. Methods Totally 116 patients with glioma confirmed pathologically were collected. Ultrasonic features were observed, including the main site of the tumor, maximum diameter, border, cystic degeneration, calcification, the degree of peritumoral edema and CDFI blood flow classification, and the correlation between ultrasonographic features and immunohistochemical results such as Ki-67 and isocitrate dehydrogenase 1 (IDH1) was analyzed. Results Univariate analysis showed that the border, peritumoral edema and CDFI blood flow were significantly different between negative and positive Ki-67 expression patients (P<0.01). The border, cystic degeneration and peritumoral edema were distinct between negative and positive IDH1 patients (P<0.01). Multivariate analysis showed that gliomas with clear border, high degree of peritumoral edema and rich CDFI blood flow tended to show positive Ki-67 expression, while those with vague border, low degree of peritumoral edema were frequently accompanied by positive IDH1 expression. Conclusion The border of gliomas, peritumoral edema and blood flow showed on ultrasonography may predict the expression of Ki-67 and IDH1. It is of great significance for preliminary evaluation on biological behaviors and prognosis of the tumors before surgical operation. |
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