| 李曼,李悦,高帅,刘明熙,周洋,左龙,胡文立,蒋涛.动态增强MRI定量评价缺血性脑白质病患者血脑屏障通透性[J].中国医学影像技术,2018,34(2):181~184 |
| 动态增强MRI定量评价缺血性脑白质病患者血脑屏障通透性 |
| Quantitative evaluation of blood-brain barrier permeability in patients with ischemic white matter lesions with dynamic contrast-enhanced MRI |
| 投稿时间：2017-08-24 修订日期：2017-12-21 |
| DOI：10.13929/j.1003-3289.201708166 |
| 中文关键词: 脑缺血 白质 血脑屏障 通透性 磁共振成像 |
| 英文关键词:Brain ischemia White matter Blood-brain barrier Permeability Magnetic resonance imaging |
| 基金项目:国家自然科学基金（81271309）。 |
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| 摘要点击次数: 1966 |
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| 中文摘要: |
| 目的 采用动态增强MRI（DCE-MRI）观察缺血性脑白质病变患者血脑屏障（BBB）通透性的改变及其与认知功能的相关性。方法 对71名受试者行常规MR、DCE-MR检查、简易智力状况检查量表（MMSE）评分及Fazekas评分，并根据Fazekas评分将其分为病例组和对照组。测量脑白质FLAIR高信号区及周围常规MRI表现正常脑白质区的渗透率（Ktrans）、渗透曲线下面积（AUC）和血浆容积分数（Vp）值，比较2组间差异，并分析各参数与MMSE评分的相关性。结果 病例组脑白质FLAIR高信号区及脑白质正常区Ktrans、AUC值均高于对照组（P均<0.001），其脑白质正常区Vp值较对照组减低（P=0.015），脑白质高信号区Ktrans、AUC值与MMSE评分呈负相关（r=-0.440、-0.540，P均<0.001）。结论 缺血性脑白质病患者脑白质FLAIR高信号区及周围脑白质表现正常区BBB通透性增加，且与认知功能相关。 |
| 英文摘要: |
| Objective To investigate the changes of blood-brain barrier (BBB) permeability and the correlation with cognitive function in patients with ischemic white matter disease with dynamic contrast-enhanced MRI (DCE-MRI). Methods Totally 71 subjects underwent routine MRI, DCE-MRI, mini-mental state examination (MMSE) and Fazekas scoring, and then were divided into patient group and control group according to the Fazekas scores. The leakage rate (Ktrans), area under the leakage curve (AUC) and fractional blood plasma volume (Vp) in cerebral white matter hyperintensities area and normal appearing white matter area were measured and compared between the two groups. The correlation between these parameters and MMSE scores were analyzed. Results Ktrans and AUC value of white matter hyperintensities area and normal appearing white matter area in patient group were significantly higher than those in control group (all P<0.001). Vp value of normal appearing white matter area in patient group was lower than that in control group (P=0.015). Ktrans and AUC value of white matter hyperintensities area in patient group had significant negative correlation with MMSE scores (r=-0.440, -0.540, both P<0.001). Conclusion BBB permeability increased in cerebral white matter hyperintensities and normal appearing white matter area in patients with ischemic white matter lesions, which correlated with cognitive function. |
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