| 段小艺,刘翔,叶佳俊,高俊刚,郑婕,郭佑民.阿尔茨海默病及轻度认知损伤患者PET与MRI分析[J].中国医学影像技术,2017,33(11):1624~1629 |
| 阿尔茨海默病及轻度认知损伤患者PET与MRI分析 |
| Analysis of PET and MRI in Alzheimer disease and mild cognitive impairment |
| 投稿时间：2017-08-07 修订日期：2017-10-16 |
| DOI：10.13929/j.1003-3289.201708031 |
| 中文关键词: 阿尔茨海默病 认知功能障碍 正电子发射型体层摄影术 磁共振成像 诊断显像 |
| 英文关键词:Alzheimer disease Cognitive dysfunction Positron-emission tomography Magnetic resonance imaging Diagnostic imaging |
| 基金项目:西安交通大学第一附属医院临床研究面上项目（XJTU1AF-CRF-2015-013）。 |
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| 中文摘要: |
| 目的 探讨PET葡萄糖代谢成像与MR结构成像诊断阿尔茨海默病（AD）与轻度认知损伤（MCI）的临床价值。方法 收集AD患者18例（AD组）、MCI患者6例（MCI组），其中AD患者包括11例中重度AD） 中重度AD组）及7例轻度AD） 轻度AD组），另招募10名健康志愿者（对照组），同期进行PET与MR结构成像，通过视觉评价与定量分析法观察脑内放射性分布及海马萎缩情况。结果 所有AD患者（18/18，100%）均可见脑内特定区域葡萄糖代谢减低，其中11例中重度AD患者均同时伴有海马萎缩，7例轻度AD患者中3例可见海马萎缩；MCI患者中，5例（5/6，83.33%）未见海马萎缩，但其中2例可见葡萄糖代谢减低。对照组（10/10，100%）均未见海马萎缩，其中2例可见轻度脑萎缩，FDG分布对称性轻度减低。结论 PET及MRI均可用于诊断AD与MCI，但各有侧重，二者联合应用有利于进一步提高对AD的诊断能力。 |
| 英文摘要: |
| Objective To observe the application value of PET glucose metabolic imaging and MR structural imaging in diagnosis of Alzheimer disease (AD) and mild cognitive impairment (MCI). Methods Totally 18 patients with AD (AD group), 6 patients with MCI (MCI group) and 10 healthy volunteers (HC group) were enrolled. There were 11 cases of moderate or severe AD and 7 cases of mild AD in AD group. PET and structural MR imaging of the brain were performed. The radioactivity distribution in the brain and the hippocampal atrophy were observed through visually evaluation and quantitative analysis. Results The glucose metabolism reduced in certain regions of the brain in all AD patients (18/18,100%). Among them, 11 patients with moderate or severe AD accompanied hippocampal atrophy, while 3 of 7 patients with mild AD showed hippocampal atrophy. No hippocampal atrophy was found in 5 patients with MCI (5/6, 83.33%), but 2 of them showed decreased radioactivity in the brain. The symmetric mild diminution of radioactivity distribution without hippocampal atrophy was found in all subjects in HC group (10/10, 100%). Two cases in HC group showed mild encephalanalosis. Conclusion Both of PET glucose metabolic imaging and MR structural imaging can be used to diagnose AD or MCI with different focus. Combination of these two techniques is helpful to improving diagnostic accuracy. |
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