徐大华,殷立平,吴意赟,周正国,李宏波,马云飞,高慧,蔡婷.CEUS评估克罗恩病活动度的可行性[J].中国医学影像技术,2017,33(5):718~721
CEUS评估克罗恩病活动度的可行性
Feasibility of CEUS in assessment of Crohn disease activity
投稿时间:2016-09-24  修订日期:2017-04-04
DOI:10.13929/j.1003-3289.201609107
中文关键词:  克罗恩病  造影剂  超声检查
英文关键词:Crohn disease  Contrast media  Ultrasonography
基金项目:江苏省中医院院级课题(Y14027)。
作者单位E-mail
徐大华 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
殷立平 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029 yinliping003@aliyun.com 
吴意赟 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
周正国 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
李宏波 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
马云飞 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
高慧 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
蔡婷 江苏省中医院 南京中医药大学附属医院超声医学科, 江苏 南京 210029  
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中文摘要:
      目的 探讨CEUS评估克罗恩病活动度的可行性。方法 回顾性分析经临床确诊为克罗恩病的39例患者,其中临床疾病活动指数(CDAI)评分<150分(缓解期)18例,150~450分(活动期)21例,分别测量肠壁厚度,对增厚肠壁根据能量多普勒超声表现进行Limberg分型,并分别进行CEUS,对比分析上升时间、峰值强度、平均渡越时间、峰值降半时间、上升斜率及达峰时间的差异。结果 活动期患者的肠壁厚度、峰值强度及上升斜率明显高于缓解期,差异均有统计学意义(P均<0.05)。活动期Limberg Ⅰ型1例,Limberg Ⅱ型4例,Limberg Ⅲ型10例,Limberg Ⅳ型6例;缓解期Limberg Ⅰ型10例,Limberg Ⅱ型7例,Limberg Ⅲ型1例。活动期肠壁血流以Limberg Ⅲ、Ⅳ型为主,缓解期以Ⅰ、Ⅱ型为主,差异有统计学意义(P<0.001)。结论 CEUS可为克罗恩病活动度的评估提供定量资料,具有一定的临床应用价值。
英文摘要:
      Objective To evaluate the feasibility of CEUS in Crohn disease (CD) activity. Methods Thirty-nine patients with CD were analyzed. The clinical disease activity index of 18 cases were less than 150 (inactivity), and 21 cases were between 150 and 450 (activity). The thickness of intestinal walls were measured and Limberg classification were determined by power-Doppler results. The CEUS was performed, and the parameters including rise time, peak intensity, mean transit time, time from peak to one half, wash in slope and time to peak were statistical analyzed. Results The thickness of the lesions, peak intensity and wash in slope of activity CD were greater than those of inactivity CD, which had significant difference (all P<0.05). The Limberg classification of type Ⅰ was 1 case, type Ⅱ was 4 cases, type Ⅲ was 10 cases and type Ⅳ was 6 cases in activity CD. The Limberg classification of type Ⅰ was 10 cases, type Ⅱ was 7 cases and type Ⅲ was 1 case. The Limberg classification were mainly type Ⅲ and type Ⅳ in activity CD, and type Ⅰand type Ⅱ in inactivity CD, which had significant difference (P<0.001). Conclusion CEUS can provide quantitative parameters in CD activity and has great clinical value.
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