| 张芳玲,易畅,余冬兰,赵彬良,史新冲,张祥松.健康人群全身动态13N-NH3·H2O PET/CT显像13N-NH3·H2O的生物分布及辐射吸收剂量评估[J].中国医学影像技术,2017,33(3):478~482 |
| 健康人群全身动态13N-NH3·H2O PET/CT显像13N-NH3·H2O的生物分布及辐射吸收剂量评估 |
| Biodistribution and estimation of radiation-absorbed dosesin humans for 13N-ammonia PET/CT |
| 投稿时间：2016-06-08 修订日期：2016-12-27 |
| DOI：10.13929/j.1003-3289.201606039 |
| 中文关键词: 正电子发射型体层摄影术 辐射剂量 健康人 13N-NH3·H2O |
| 英文关键词:Positron-emission tomography Radiation dosage Healthy adult 13N-ammonia |
| 基金项目:国家自然科学基金（81271599）。 |
|
| 摘要点击次数: 2431 |
| 全文下载次数: 840 |
| 中文摘要: |
| 目的 探讨健康人群13N-NH3·H2O PET/CT显像中13N-NH3·H2O的生物分布和主要器官的辐射吸收剂量。方法 对5名健康志愿者在注射666~814 MBq 13N-NH3·H2O后进行全身PET/CT扫描，获得每名受试者的连续动态图像。通过CT二维轴位图像手动勾画ROI，并在PET图像中找出相应层面，按照医学内照射剂量计算（MIRD）方法评估13N-NH3·H2O的吸收剂量。结果 心脏、肝及双肾13N-NH3·H2O摄取最高，其次为胰腺、脑组织、脾脏和胃。心脏的吸收剂量最高，为（7.14±3.63）×10-3 mGy/MBq。受试者全身辐射吸收剂量为（2.11±0.44）×10-3 mGy/MBq，全身有效剂量为（6.58±1.23）×10-3 mSv/MBq。结论 13N-NH3·H2O作为重要的心肌显像示踪剂，用于人体全身PET/CT显像的辐射剂量是安全的。 |
| 英文摘要: |
| Objective To evaluate the biodistribution and radiation-absorbed doses of main organs in healthy people with 13N-ammonia. Methods Five healthy volunteers underwent whole-body PET and CT scans after injection of 666-814 MBq of 13N-ammonia. The serial dynamic emission images of each healthy volunteer were acquired. ROI were drawn manually based on the transverse CT images and transferred to the corresponding PET slices. Radiation-absorbed doses were calculated using the medical internal radiation dosimetry (MIRD) method. Results The highest concentrations of 13N-ammonia were found in the heart, liver and kidneys, followed by pancreas, brain, spleen and stomach. The organ of highest absorbed dose was heart with (7.14±3.63)×10-3 mGy/MBq. The whole-body absorbed dose was (2.11±0.44)×10-3mGy/MBq. The whole-body effective dose was (6.58±1.23)×10-3 mSv/MBq. Conclusion As one of the most important myocardial perfusion tracers, the whole-body 13N-NH3·H2O PET appears to be safe for humans. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
