| 曹崑,王帅,赵博,孙应实.3.0T磁共振多b值扩散加权成像ADC值反映宫颈鳞癌强化和分化程度的可行性[J].中国医学影像技术,2017,33(3):423~427 |
| 3.0T磁共振多b值扩散加权成像ADC值反映宫颈鳞癌强化和分化程度的可行性 |
| Feasibility of ADC reflecting enhancement and differentiation of cervical squamous cell carcinomas in multi-b-value DWI on 3.0T MRI |
| 投稿时间：2016-07-04 修订日期：2016-12-14 |
| DOI：10.13929/j.1003-3289.201607015 |
| 中文关键词: 宫颈肿瘤 扩散磁共振成像 分化程度 |
| 英文关键词:Uterine cervical neoplasms Diffusion magnetic resonance imaging Differentiation grade |
| 基金项目:国家自然科学基金（81402167）、首都卫生发展科研专项项目（2014-4-2155）。 |
|
| 摘要点击次数: 1977 |
| 全文下载次数: 877 |
| 中文摘要: |
| 目的 探讨3.0T MRI的多b值DWI中ADC值反映宫颈鳞癌灶强化程度及分化程度的可行性。方法 回顾性分析31例经病理确诊为宫颈鳞癌患者的多b值DWI及多时相增强扫描图像，勾画癌灶高、低强化区，计算不同b值下的ADC值及信号强度的强化幅度。分析不同高低b值组合下的ADC差值与早、晚期强化幅度的相关性，以及ADC值和ADC差值与鳞癌分化程度的关系。结果 不同b值时宫颈鳞癌高低强化区的ADC值随b值增高呈逐渐降低趋势。b值为200 s/mm2时，与高b值（800、1 000、1 200、1 400 s/mm2）组合后ADC差值与早期强化幅度呈弱相关（r=0.315~0.339，P均<0.05）。b值为800、1 000 s/mm2时，中高分化癌灶高强化区域的ADC值明显高于低分化癌灶（P均<0.05），余b值下不同分化癌灶ADC值及不同b值下ADC差值差异均无统计学意义（P均>0.05）。低强化区的各ADC值及ADC差值在不同分化癌灶间差异均无统计学意义（P均>0.05）。结论 多b值组合可用于反映宫颈癌血供及分化程度，其中采用3.0T MR DWI检查宫颈鳞癌的b值可为200 s/mm2和800 s/mm2或1 000 s/mm2。 |
| 英文摘要: |
| Objective To investigate the feasibility of ADC values that derived from MR DWI with multiple b values in reflecting the amplitude of enhancement and degree of differentiation in cervical squamous cell carcinomas on 3.0T MR scanner. Methods DWI and multiple phase contrast enhanced MRI images of 31 patients with pathologically diagnosed cervical squamous cell carcinomas were retrospectively analyzed. All ADC values in different b values and the amplitude of signal intensity enhancement were measured in various areas of tumors. Correlations of differences of ADCs in high and low b values with early and late enhancement, and the relationship of ADC and differences of ADCs with pathologically tumor differentiation grades were analyzed. Results ADC value in high and low enhanced areas of cervical cancer was inversely related with different b values. Differences of ADCs between low b value (200 s/mm2) and high b values (800, 1 000, 1 200, 1 400 s/mm2) had weak positive correlation with early enhancement (r=0.315-0.339, all P<0.05). While b=800 s/mm2 and 1 000 s/mm2, ADCs in highly enhanced areas of tumor were significantly lower in well-differentiated cancer lesions compared with those of poorly differentiated cancer lesions. There was no statistically significant of ADC value in other b values, and also of differences of ADCs in all b values in different differentiation foci (all P>0.05). No differences were found in ADC values under other b values in various degree of differentiation foci, nor in differences of ADCs in all b values (all P>0.05). Conclusion Combination of multiple b values of DWI may have the potential to reflect blood supply and tumor differentiation grades in cervical squamous cell carcinomas, while low b value of 200 s/mm2 and high b values of 800 s/mm2 and 1 000 s/mm2 will be the preferable choice on 3.0T MR scanner. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
