| 张林启,覃艺芳,李伟,张汝森,伍秀青,袁道彰,任志刚,李雯,李靖,钟熹.常规SPECT/CT断层融合显像诊断高危前列腺癌患者骨转移[J].中国医学影像技术,2017,33(2):260~264 |
| 常规SPECT/CT断层融合显像诊断高危前列腺癌患者骨转移 |
| Routine SPECT/CT fusion imaging in diagnosis of bone metastasis patients with high-risk prostate cancer |
| 投稿时间：2016-07-29 修订日期：2016-11-21 |
| DOI：10.13929/j.1003-3089.201607124 |
| 中文关键词: 前列腺肿瘤 骨 肿瘤转移 体层摄影术,发射型计算机,单光子 同位素标记 |
| 英文关键词:Prostate neoplasms Bone Neoplasm metastases Tomography,emission-computed,single-photon Isotope labeling |
| 基金项目:广东省医学科学技术研究基金（A2016611）。 |
| 作者 | 单位 | E-mail | | 张林启 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 覃艺芳 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 李伟 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 张汝森 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 伍秀青 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 袁道彰 | 广州医科大学附属肿瘤医院泌尿外科, 广东 广州 510095 | daozhangyuan@163.com | | 任志刚 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 李雯 | 广州医科大学附属肿瘤医院核医学科, 广东 广州 510095 | | | 李靖 | 广州医科大学附属肿瘤医院泌尿外科, 广东 广州 510095 | | | 钟熹 | 广州医科大学附属肿瘤医院放射科, 广东 广州 510095 | |
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| 中文摘要: |
| 目的 探讨常规SPECT/CT断层融合显像诊断高危前列腺癌患者骨转移的价值。方法 前瞻性连续的收集53例初诊为高危前列腺癌的患者进行常规全身骨显像（WBS）及SPECT/CT断层融合显像；对所有患者病灶的WBS、SPECT/CT图像进行定性分析，计算WBS、SPECT/CT显像诊断前列腺癌骨转移的准确率。结果 符合纳入标准的患者46例，20例患者共85个病灶确诊为骨转移；以患者为单位，SPECT/CT的诊断准确率为89.13%（41/46），明显高于WBS（27/46，58.70%；χ2=11.05，P=0.001），SPECT/CT诊断骨转移的灵敏度为90.00%（18/20），高于WBS；以病灶为单位SPECT/CT诊断的准确率为97.84%（136/139），高于WBS，SPECT/CT诊断骨转移的灵敏度为100%（85/85），高于WBS。结论 常规SPECT/CT断层融合显像能早期发现、准确诊断高危前列腺癌患者的骨转移。 |
| 英文摘要: |
| Objective To explore the value of routine 99Tcm-MDP SPECT/CT image in diagnosis of bone metastasis for the patient with high-risk prostate cancer (PCa).Methods Totally 53 consecutive patients with newly diagnosed high-risk PCa were enrolled. All patients underwent whole-body scintigraphy (WBS), followed by whole-body SPECT/CT fusion imaging. Images of WBS and SPECT/CT were analyzed qualitativly. Sensitivity and accuracy of WBS, SPECT/CT in diagnosis of bone metastasis were calculated.Results Fourty-six patients were included in the study. Bone metastases were confirmed in 20 patients with 85 lesions. The diagnosis accuracy of SPECT/CT was 89.13% (41/46) on a per-patient basis, significantly higher than that of WBS (27/46, 58.70%; χ2=11.05, P=0.001). Sensitivity of SPECT/CT in diagnosis of bone metastasis was 90.00% (18/20) on a per-patient basis, significantly higher than that of WBS (7/20, 35.00%; χ2=12.91, P<0.001). The diagnosis accuracy of SPECT/CT was 97.84% (136/139) on all per-lesion basis, significantly higher than that of WBS (98/139, 70.50%; χ2=38.99, P<0.001); Sensitivity of SPECT/CT in diagnosis of bone metastasis was 100% (85/85) on all per-lesion basis, significantly higher than that of WBS (76/85, 89.41%; χ2=9.50, P=0.002).Conclusion SPECT/CT contributes to early detection and exact diagnosis of bone metastases. |
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