| 朱海滨,李晓婷,刘玉良,孙应实.直肠癌磁共振体素内不相干运动成像定量参数与Ki-67表达水平的相关性分析[J].中国医学影像技术,2017,33(2):237~241 |
| 直肠癌磁共振体素内不相干运动成像定量参数与Ki-67表达水平的相关性分析 |
| Relationship between parameters of intravoxel incoherent motion imaging with Ki-67 expression level in rectal adenocarcinoma |
| 投稿时间：2016-10-08 修订日期：2016-11-09 |
| DOI：10.13929/j.1003-3089.201610017 |
| 中文关键词: 直肠肿瘤 体素内不相干运动 扩散加权成像 Ki-67 |
| 英文关键词:Rectal neoplasms Intravoxel incoherent motion imaging Diffusion-weighted imaging Ki-67 |
| 基金项目:国家自然科学基金（81471640、81371715）。 |
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| 中文摘要: |
| 目的 探讨直肠癌体素内不相干运动成像（IVIM）定量参数值与Ki-67表达水平的相关性。方法 86例未接受新辅助治疗而直接经手术证实的直肠腺癌患者接受直肠多b值DWI检查（b=0、20、50、100、200、400、600、800、1 000、1 200、1 400、1 600 s/mm2），测量病灶相应的D、D*、f值。按Ki-67水平将其分为低表达组（Ki-67<50%）和高表达组（Ki-67≥50%），比较两组多b值定量参数有无差异并分析其与Ki-67表达水平的相关性，并采用多因素回归分析Ki-67指数增殖程度与临床病理结果和MR参数的关系。结果 直肠癌低表达组与高表达组的平均D、f值分别为，差异有统计学意义（P<0.01；P=0.01），两组间D*值差异无统计学意义。D值与Ki-67表达水平呈负相关（r=-0.40，P<0.01）。多因素回归分析提示仅D值是高Ki-67表达的独立危险因子。结论 直肠癌D值与Ki-67表达相关，可间接评估直肠肿瘤细胞增殖情况及预后，反映直肠癌的侵袭性和生物学特性。 |
| 英文摘要: |
| Objective To explore the relationship between parameters of intravoxel incoherent motion imaging and the molecular markers Ki-67 in rectal cancer patients.Methods Totally 86 patients with rectal cancer confirmed by surgery and without receiving chemoradiotherapy were included in this retrospective study. All patients underwent multiple b-values (b=0, 20, 50, 100, 200, 400, 600, 800, 1 000, 1 200, 1 400, 1 600 s/mm2) DWI before any anticancer treatment. The patients were divided into low Ki-67 group (Ki-67<50%) and high Ki-67 group (Ki-67 ≥ 50%) according to Ki-67 level. Relationship between the quantitative parameters from IVIM model and Ki-67 level were assessed. The relationship among Ki-67 level, clinicopathological outcomes and MR parameters was analyzed using linear regression analysis.Results In high Ki-67 group, the mean D, f value had significantly differences compared with those of the low-Ki-67 group. However, the mean D* values had no difference between two groups (×10-3 mm2/s vs×10-3 mm2/s, P=0.41). There was a negative correlation between Ki-67 level and D values (r=-0.40, P<0.01). In addition, of all these variables, a higher D values independently predicted a high Ki-67 status.Conclusion Significant correlations are observed between pre-treatment D values and Ki-67 level of rectal cancer. It suggests that D value from IVIM model may be used as a noninvasive biomarker for evaluation the biological features of rectal cancer before treatment. |
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