| 路涛,蒲红,陈光文.胃肠胰神经内分泌肿瘤的影像表现及其病理特征[J].中国医学影像技术,2016,32(11):1701~1705 |
| 胃肠胰神经内分泌肿瘤的影像表现及其病理特征 |
| Imaging and clinicopathologic features of gastroenteropancreatic neuroendocrine neoplasms |
| 投稿时间：2016-02-25 修订日期：2016-07-20 |
| DOI：10.13929/j.1003-3289.2016.11.019 |
| 中文关键词: 胃肠胰神经内分泌肿瘤 体层摄影术,X线计算机 磁共振成像 |
| 英文关键词:Gastroenteropancreatic neuroendocrine neoplasms Tomography, X-ray computed Magnetic resonance imaging |
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| 中文摘要: |
| 目的 探讨胃肠胰神经内分泌肿瘤（GEP-NENs）的影像表现及其病理特征。方法 回顾性分析48例经病理证实为GEP-NENs患者的影像及临床资料，其中33例胃肠道NENs患者均接受CT检查；15例胰腺NENs患者中，9例只接受CT检查，4例只接受MR检查，2例同时接受CT及MR检查。分析其影像学表现及病理特征。结果 48例GEP-NENs患者中，15例（15/48，31.25%）位于胰腺，其次为胃部12例（12/48，25.00%）和直肠11例（11/48，22.92%），其他部位较少见。G1级12例（12/48，25.00%），G2级11例（11/48，22.92%），G3级20例（20/48，41.67%），混合腺NENs有5例（5/48，10.42%）。突触素阳性46例（46/48，95.83%），嗜铬粒蛋白A阳性36例（36/48，75.00%）。胰腺NENs主要位于胰头及体尾部，大小、形状、生长方式不一，可有囊变坏死及钙化；CT平扫呈等或低密度；MR平扫T1WI为等（低）信号，T2WI为等（高）信号，增强后强化方式多样。33例胃肠NENs CT平扫可见管壁增厚或局部软组织结节、肿块影；增强扫描12例（12/33，36.36%）呈均匀中度强化，11例（11/33，33.33%）呈不均匀且不规则强化。结论 胰腺、胃、直肠是GEP-NENs的好发部位，其临床症状及影像表现均不具特异性。 |
| 英文摘要: |
| Objective To explore the imaging and clinicopathologic features of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Methods Images and clinical datum of 48 GEP-NENs patients confirmed by pathology were retrospective analyzed. Thirty-three gastrointestinal NENs patients all underwent CT examination. Among 15 pancreatic NENs patients, 9 cases only underwent CT examination, 4 cases only underwent MR examination, 2 cases underwent CT and MR examination. Image and pathology evaluation were carried out. Results Fifteen (15/48, 31.25%) of 48 GEP-NENs patients was in pancreas, and 12 patients (12/48, 25.00%) were in stomach, 11 patients (11/48, 22.92%) were in rectum, rest parts rarely occurred. There were 12 cases (12/48, 25.00%) G1 grade, 11 cases (11/48, 22.92%) G2 grade, 20 cases (20/48, 41.67%) G3 grade, 5 cases (5/48, 10.42%) mixed gland NENs. There were synaptophysin positive 46 cases (46/48, 95.83%) and chromogranin A positive 36 cases (36/48, 75.00%). Pancreatic NENs were mainly located in the head, body and tail of pancreas, with different sizes, morphology and growth patterns. Necrosis and calcification were seen in the tumors. CT plain scan showed iso-density or low-density. MR T1WI showed iso-intensity (hypo-intensity), and T2WI showed iso-intensity (hyper-intensity). Enhanced MR showed various enhanced patterns. CT plain scan images of 33 gastrointestinal NENs mainly showed thickening walls or nodules and masses in local area, and enhanced CT scan mainly showed moderately homogeneous enhancement in 12 patients (12/33, 36.36%) or irregularly heterogeneous enhancement in 11 patients (11/33, 33.33%). Conclusion GEP-NENs mainly occurs in pancreas, stomach and rectum, and its clinical symptoms and imaging finding are nonspecific. |
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