| 马荣,崔盟,张冬,史长征,罗良平.磁共振R2* mapping评估大鼠急性放射性肝损伤模型早期肝纤维化[J].中国医学影像技术,2016,32(11):1644~1648 |
| 磁共振R2* mapping评估大鼠急性放射性肝损伤模型早期肝纤维化 |
| R2* mapping in evaluating early stage of liver fibrosis in rats with acute radiation induced liver injury |
| 投稿时间：2016-05-20 修订日期：2016-08-27 |
| DOI：10.13929/j.1003-3289.2016.11.003 |
| 中文关键词: 磁共振成像 肝纤维化 |
| 英文关键词:Magnetic resonance imaging Liver fibrosis |
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| 中文摘要: |
| 目的 探讨MR R2* mapping技术评估SD大鼠急性放射性肝损伤模型早期肝纤维化的可行性。方法 将30只SD大鼠随机平均分为3组，以固定剂量对大鼠右半肝进行单次放疗，制备急性放射性肝损伤大鼠模型。于放疗前、放疗后1个月（A组）、2个月（B组）和3个月（C组），分别行T1WI、T2WI及R2*扫描。扫描后处死大鼠行病理学检查、评估肝纤维化分期。测定大鼠左、右半肝的T1WI和T2WI的信号强度及R2*值，分析R2*值与大鼠肝纤维化病理分期的相关性。结果 最终7只大鼠死亡，A组8只、B组8只、C组7只纳入研究。A、B、C组大鼠肝左叶及右叶相对T1、T2值差异无统计学意义（P均>0.05）。放疗后3组肝右叶R2*值均高于肝左叶（P均<0.05）。3组组间两两比较，肝右叶R2*值随放疗后时间延长而升高（P均<0.05），肝左叶的R2*值差异均无统计学意义（P均>0.05）。放疗前大鼠肝右叶R2*值为（38.42±5.69）Hz，S0期大鼠肝右叶R2*值为（50.75±6.12）Hz，S1期为（58.73±6.40）Hz，S2期（64.34±5.87）Hz。肝右叶R2*值与病理分期呈高度正相关（rs=0.819，P<0.05）。结论 R2*值可用于准确反映SD大鼠急性放射性肝损伤模型早期纤维化程度。 |
| 英文摘要: |
| Objective To explore the feasibility of R2* mapping in evaluating early stage of liver fibrosis in SD rats with acute radiation induced liver injury (RILI). Methods Totally 30 SD rats were divided into 3 groups randomly (each n=10). Each rat received single irradiation at same dose on the right liver to create a RILI model. After acquisition of MR T1WI, T2WI and R2* sequence 1st (group A), 2nd (group B), 3rd month (group C) after irradiation, rats were sacrificed to take histopathology exams for evaluating the stage of liver fibrosis. The R2* and T1, T2 values of right and left livers were measured at different time, and the relation of R2* values and stage of liver fibrosis were evaluated. Results In the end 7 rats died, and there were 8 rats of group A, 8 rats of group B, 7 rats of group C. The T1, T2 value of right and left livers showed no differences within three groups (all P>0.05). Three groups in post-radiation had a higher R2* value on right liver compared to left sides (P<0.05). R2* on right liver increased with the time increasing (all P<0.05), meanwhile no significant change were revealed on left liver (all P>0.05). The R2* value of pre-radiation and S0, S1, S2 liver fibrosis were (38.42±5.69)Hz, (50.75±6.12)Hz, (58.73±6.40)Hz and (64.34±5.87)Hz on right liver, which showed a highly positive correlations with histopathology stages (rs=0.819, P<0.05). Conclusion R2* value can be used to reflect the early stage of liver fibrosis in SD rats with RILI. |
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