| 高鹏飞,谢钧韬,徐哲,谢新立,王家祥,周李.18F-FDG PET/CT在小儿神经母细胞瘤中的应用[J].中国医学影像技术,2016,32(9):1376~1380 |
| 18F-FDG PET/CT在小儿神经母细胞瘤中的应用 |
| Application of 18F-FDG PET/CT in pediatric neuroblastoma |
| 投稿时间：2016-02-20 修订日期：2016-07-25 |
| DOI：10.13929/j.1003-3289.2016.09.016 |
| 中文关键词: 儿童 神经母细胞瘤 18F氟脱氧葡萄糖 正电子发射型体层摄影术 |
| 英文关键词:Child Neuroblastoma Fluorodeoxyglucose 18F Positron-emission tomography |
| 基金项目:广东省科技计划社会发展基金（2012B031800297）。 |
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| 中文摘要: |
| 目的 探讨18F-FDG PET/CT在小儿神经母细胞瘤（NB）中的应用价值。方法 回顾性分析20例经病理确诊的NB患儿的临床资料，对所有患儿均行18F-FDG PET/CT检查，测量病灶的最大标准化摄取值（SUVmax），采用秩和检验比较治疗前组及治疗后组SUVmax的差异；采用Spearman相关性分析评估神经元特异性烯醇化酶（NSE）与病灶SUVmax的相关性。结果 根据18F-FDG PET/CT及国际神经母细胞瘤分期系统（INSS）进行分期:8例治疗前患儿中Ⅱ期1例、Ⅲ期3例、Ⅳ期4例；12例治疗后患儿中Ⅱ期1例、Ⅲ期2例、Ⅳ期9例。治疗前组、治疗后组NB患儿瘤体SUVmax分别为4.73±；1.43、1.64±；0.67（W=78.500，P<0.001）。20例患儿NSE为（70.92±；85.61）ng/ml，SUVmax为2.88±；1.85，二者呈正相关（r=0.699，P<0.05）。结论 18F-FDG PET/CT可辅助对NB患儿进行临床分期、监测化疗前后瘤体性质、并判断合适的手术时机。 |
| 英文摘要: |
| Objective To explore the application of 18F-FDG PET/CT in pediatric neuroblastoma (NB). Methods A total of 20 cases diagnosed as pediatric NB according to pathological results were retrospectively analyzed. The patients underwent 18F-FDG PET/CT scan, and then the maximum standardized uptake value (SUVmax) were measured. The difference of SUVmax between prior-treatment group (n=8) and post-treatment group (n=12) was compared by Rank sum test, and the correlation between neuronspecific enolase (NSE) and SUVmax was analyzed by Spearman correlation analysis. Results According to 18F-FDG PET/CT and international neuroblastoma staging system (INSS), there were 1 case of stage Ⅱ, 3 cases of stage Ⅲ, 4 cases of stage Ⅳ in priortreatment group, and 1 case of stage Ⅱ, 2 cases of stage Ⅲ, 9 cases of stage Ⅳ in the post-treatment group. The SUVmax of prior-treatment group and post-treatment group were 4.73±1.43 and 1.64±0.67 (W=78.500, P<0.001). The NSE of total 20 cases was (70.92±85.61)ng/ml, and the positive correlation was found with SUVmax (2.88±1.85; r=0.699, P<0.05). Conclusion 18F-FDG PET/CT plays a significant role in the process of clinical staging of pediatric NB, the monitoring of tumor features before and after chemotherapy, and the judgment of timing operation. |
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