| 王瑞珠,杨明,席艳丽,朱明水.1H-MRS评价新生儿缺氧缺血性脑病[J].中国医学影像技术,2016,32(8):1175~1178 |
| 1H-MRS评价新生儿缺氧缺血性脑病 |
| 1H-MRS in evaluation of hypoxic-ischemic encephalopathy on neonates |
| 投稿时间：2015-12-23 修订日期：2016-05-20 |
| DOI：10.13929/j.1003-3289.2016.08.007 |
| 中文关键词: 婴儿,新生 缺氧缺血性脑病 磁共振波谱 磁共振成像 |
| 英文关键词:Infant, newborn Hypoxic-ischemic encephalopathy Magnetic resonance spectroscopy Magnetic resonance imaging |
| 基金项目:南京市科技发展项目基金（YKK14117）。 |
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| 中文摘要: |
| 目的 探讨1H-MRS评价新生儿缺氧缺血性脑病（HIE）的价值。方法 收集经临床确诊的足月HIE患儿30例（HIE组）和无神经系统异常新生儿16例（对照组）。于出生后22天内行头颅1H-MRS扫描，分别计算胆碱/肌酸（Cho/Cr）、N-乙酰天门冬氨酸/肌酸（NAA/Cr）、N-乙酰天门冬氨酸/胆碱（NAA/Cho）、乳酸/肌酸（Lac/Cr）比值，并进行统计学分析。结果 与对照组比较，HIE组Lac/Cr升高（P<0.05），NAA/Cr，NAA/Cho均降低（P均<0.05），Cho/Cr差异无统计学意义（P>0.05）。多因素Logistic回归分析结果示NAA/Cr、Lac/Cr是HIE的独立危险因素（P均<0.05）。结论 1H-MRS可客观反映HIE患儿缺氧缺血后代谢变化，更好地评价脑损伤的严重程度，有助于HIE的早期诊断及治疗。 |
| 英文摘要: |
| Objective To explore the value of 1H-MRS in evaluation of hypoxic-ischemic encephalopathy (HIE) in neonates. Methods Totally 30 full-term neonates with HIE confirmed by clinic (HIE group) and 16 infants without nervous system abnormalities (control group) were collected. Cerebral 1H-MRS was performed within 22 days after birth. Choline/creatine (Cho/Cr), N-acetylaspartate/creatine (NAA/Cr), N-acetylaspartate/choline (NAA/Cho), lactic acid/creatine (Lac/Cr) were canculated respectively, and statistical analysis was carried out. Resluts Compared to control group, Lac/Cr in HIE group was statistically increased (P<0.05), and NAA/Cr, NAA/Cho were both statistically decreased (both P<0.05). The difference of Cho/Cr between 2 groups had no statistical significance (P>0.05). Logistic regression analysis showed NAA/Cr and Lac/Cr were independent risk factors of HIE (both P<0.05). Conclusion 1H-MRS can objectively reflect brain metabolic changes of HIE, and it is a usful method to evaluate brain injury. |
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