| 刘健萍,赵海,高明勇,谢海群,卢瑞梁,梁雪梅.基于动脉自旋标记及DTI评价脑小血管病患者脑灌注及白质微结构变化[J].中国医学影像技术,2016,32(8):1170~1174 |
| 基于动脉自旋标记及DTI评价脑小血管病患者脑灌注及白质微结构变化 |
| Arterial spin labeling and DTI in evaluation on cerebral perfusion and white matter of cerebral small vessel disease patients |
| 投稿时间：2016-01-26 修订日期：2016-04-12 |
| DOI：10.13929/j.1003-3289.2016.08.006 |
| 中文关键词: 脑小血管病 磁共振成像 扩散张量成像 动脉自旋标记 |
| 英文关键词:Cerebral small vessel disease Magnetic resonance imaging Diffusion tensor imaging Arterial spin labeling |
| 基金项目:广东省医学科研基金项目（A2015546）、佛山市医学科研基金项目（2015189）。 |
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| 中文摘要: |
| 目的 应用动脉自旋标记（ASL）及DTI技术探讨脑小血管病（cSVD）患者常规扫描表现正常白质（NAWM）区脑灌注及白质微结构变化。方法 对23例cSVD患者（cSVD组）及13名年龄、性别匹配的健康志愿者（对照组）行常规MR、ASL及DTI检查，测量双侧额叶、顶叶、半卵圆中心、胼胝体膝部及压部常规扫描NAWM区的各向异性分数（FA）值、表观扩散系数（ADC）值、脑血流量（CBF）值，比较cSVD组与对照组间的差异，并进一步分析cSVD组FA值及ADC值与CBF值的相关性。结果 cSVD组双侧额叶、顶叶FA值较对照组减低，ADC值升高（P均<0.05）；双侧半卵圆中心FA值及右侧半卵圆中心CBF值均较对照组减低（P均<0.05）。双侧额叶、顶叶白质及右侧半卵圆中心的FA值与CBF呈正相关（r=0.51、0.46、0.22、0.27、0.33，P均<0.05），双侧额叶ADC与CBF值呈负相关（r=-0.50、-0.38，P均<0.05）。结论 DTI能反映cSVD患者早期隐匿性脑白质损伤，以双侧额叶FA值改变最为明显。 |
| 英文摘要: |
| Objective To explore the occult damages of normal appearing white matter (NAWM) in patients with small vessel disease (cSVD) with DTI and arterial spin labeling (ASL) techniques. Methods Twenty-three patients with cSVD (cSVD group) and 13 matched volunteers (control group) underwent conventional MR, DTI and ASL examinations. Fractional anisotropy (FA), apparent diffusion coefficient (ADC) values and cerebral blood flow (CBF) were measured symmetrically on bilateral frontal and parietal lobes white matter, centrum semiovale, genu and splenium of corpus callosum and compared between the two groups. Pearson correlation analysis was used to determine the correlation of FA, ADC value with CBF. Results FA value on bilateral frontal and parietal lobes NAWM in cSVD group were lower than those in control group, and ADC value were higher than control group. Compared with control group, the decreased FA value on bilateral centrum semiovale and decreased CBF on right centrum semiovale was demonstrated in cSVD group. In cSVD group, the FA value of bilateral frontal and parietal lobes NAWM, and right centrum semiovale were positively correlated with CBF (r=0.51, 0.46, 0.22, 0.27, 0.33, all P<0.05) and the ADC value of bilateral frontal lobes NAWM were negatively correlated with CBF (r=-0.50, -0.38, both P<0.05). Conclusion The occult damage of NAWM can be detected using DTI and ASL techniques. |
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