| 岳征,蒋奕,王静,王健,赵建卿,何翼彪,刘文亚.能谱CT评价实验小型猪肝血管影像[J].中国医学影像技术,2016,32(8):1155~1159 |
| 能谱CT评价实验小型猪肝血管影像 |
| Spectral CT in evaluation on hepatic vessels imaging of experimental mini-pig |
| 投稿时间：2016-01-13 修订日期：2016-04-25 |
| DOI：10.13929/j.1003-3289.2016.08.001 |
| 中文关键词: 体层摄影术,X线计算机 肝血管 动物实验 |
| 英文关键词:Tomography, X-ray computed Hepatic vessels Animal experimentation |
| 基金项目:国家自然科学基金（81460280）。 |
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| 中文摘要: |
| 目的 评价能谱CT不同能量成像条件下实验小型猪肝血管影像图像质量，以确定最佳延迟扫描时间和单能图像。方法 对9头小型猪均行常规宝石能谱成像（GSI）扫描，而后注入对比剂，应用智能追踪（Smart Prep）技术对肝脏行动脉期扫描，延迟35、50、70 s分别釆集能谱CT增强图像。测量各延迟时间肝动脉、门静脉、肝静脉、肝实质CT值，计算门静脉与肝实质CT值的差值、肝静脉与肝实质CT值的差值，获得上述差值的峰值，比较不同延迟时间门静脉、肝静脉、肝实质CT值及其差值，确定小型猪门静脉期及静脉期最佳延迟时间。以5 keV为间距，选取40～140 keV的21个单能图像，测量三期图像的SNR、CNR和噪声，确定三期实验小型猪的最佳单能量图像。2名医师在盲法下对重建图像进行主观图像质量评分，一致性评估采用Kappa检验。结果 不同延迟时间门静脉CT值、肝静脉CT值、门静脉与肝实质CT值的差值、肝静脉与肝实质CT值的差值差异均有统计学意义（P均<0.05），不同延迟时间肝实质CT值差异无统计学意义（P>0.05）。门静脉与肝实质CT值差值的峰值出现时间为延迟50 s，肝静脉与肝实质CT值差值的峰值出现时间为延迟70 s。在65 keV水平，三期图像SNR和CNR均较高，噪声较低。2名医师对三期重建图像的各项评分均≥3分，且均具有中等以上的一致性（Kappa=0.769、0.609、0.727）。结论 动脉期扫描后延迟50 s是能谱CT观察实验小型猪门静脉期的最佳延迟时间，延迟70 s是观察静脉期的最佳延迟时间；65 keV图像是观察实验小型猪肝动脉期、门静脉期及静脉期的最佳单能图像。 |
| 英文摘要: |
| Objective To evaluate the hepatic vessels image quality of experimental mini-pig with different energy of spectral CT scanning, in order to determine the optimal delay time and monochromatic image. Methods All of 9 pigs underwent conventional gemstone spectral imaging (GSI) mode scan. Smart Prep was used to monitor the hepatic arterial phase scan after the initiation of injection, while spectral CT enhanced images were collected at 35, 50 and 70 s after the start of the arterial phase scan. CT values of hepatic artery, portal vein, and hepatic vein and liver parenchyma were measured at each delay time point. The difference between the CT value of portal vein and liver parenchyma, hepatic vein and liver parenchyma were calculated, and the peak values of the difference were calculated. CT values of hepatic vein, portal vein and liver parenchyma in different delay time were compared, and the optimal delay time of the portal venous phase and venous phase of mini-pig were determined. SNR, CNR and noise of the three phases images were compared among the 21 monochromatic energy images from 40 keV to 140 keV in an interval of 5 keV, and the optimal energy image of the three phases were determined. The subjective image quality scores of the reconstructed images were performed by 2 physicians blindly. Inter-observer agreement for evaluating image quality grading were assessed by Kappa statistics. Results There were significant differences of CT values of hepatic vein, portal vein, hepatic vein and liver parenchyma CT value, portal vein and liver parenchyma CT values among different delay time (all P<0.05). There was no significant difference of CT values of liver parenchyma among different delay time (P>0.05). The peak time of the difference between portal veins and liver parenchyma CT values was delay 50 s. The peak time of the difference between hepatic veins and liver parenchyma CT values was delay 70 s. On mono-energetic level of 65 keV, the higher SNR, CNR and lower noise were found in all of three delay phases. All of the three phases images scores by 2 physicians were ≥3 points, and had medium consistency (Kappa=0.769, 0.609, 0.727). Conclusion After starting the arterial phase scan, delay 50 s is considered to be the optimal time for the spectral CT to observe vein phase of the experimental mini-pig, delay 70 s is the optimal time to observe the venous phase; 65 keV image is the best mono-energetic image of observing hepatic arterial phase, portal venous phase and venous phase of the experimental mini-pig. |
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